The objective of the present investigation was to prepare orodispersible tablets of deferasirox by direct compression using sodium starch glycolate and crospovidone as superdisintegrants. Microcrystalline cellulose was used as diluent, mannitol and sodium saccharine to enhance mouth feel. The drug and excipients compatibility study was performed by FTIR and DSC to check purity and to show any possible interaction. The blend of all formulations were evaluated for various precompression parameters such as angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio. The prepared tablets were evaluated for weight variation, hardness, in-vitro disintegration time, in-vivo disintegration time, wetting time and in-vitro dissolution. Results showed that out of nine formulations studied, D2 showed short dispersion time with maximum drug release in 12 minutes. Combinations of superdisintegrants were found to be better in the formulation to achieve fast dissolution of tablets of deferasirox rather than using them alone in the formulation.
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